The global competition, called 100&Change promised $100 million to whatever group could come up with the best solution to improve humanity.

The four finalists include Catholic Relief Services, which seeks to remake how developing world orphanages operate by transitioning to a more family-centric style of care.

HarvestPlus expects to address hard-to-spot nutrition and hunger problems and boost farmer incomes by enabling them to grow bio-fortified crops in Africa. The goal is to reach 100 million people across 17 countries within the next five years.

The Rice 360 Institute for Global Health has proposed a fleet of neo-natal care tech that’s adaptable to “low-resource settings,” according to a press release, which should dramatically increase newborn survival rates in those areas.

Finally, a partnership between Sesame Workshop and the International Rescue Committee plans to use the Sesame Street‘s proven formula for education to promote learning among refugee children in a way that also reduces the toxic stress they may be dealing with after fleeing violent and war-torn regions in Iraq and Syria.

Read the full article on big ideas by Ben Paynter at FastCompany